Dr. Tanay Kesharwani

Benzo[b]thiophene scaffolds form the backbone of many pharmaceutical products. Their uses in medicinal chemistry include antidepressants, anti-inflammatories, and anti-tumor among other possibilities. In the traditional multi-step synthesis, the product needs purification after each step1,2 . This can lead to increased chemical waste and loss of product. Further exploration into this field could yield more efficient synthesis, as well as create a foundation capable of being altered with different substituents for varied applications.

Studying the energy of a band gap in molecules has valuable applications in semiconductor physics. The energy of a band gap refers to the energy difference between the Highest Occupied Molecular Orbital (HOMO) and Lowest Unoccupied Molecular Orbital (LUMO) or the top of the valence band and the bottom of the conduction band. A lower band gap energy corresponds to higher efficiency or lower wavelength. Studying the conductivity of organic molecules is a very useful field since organic compounds are more versatile and cheaper to produce than regular silicon semiconductors. This has a wide array of applications, especially in LEDs and micro processing units.

Molecular machines combine the fundamentals of physics and chemistry to progress a variety of fields from medicine to material science.1 These specific arrangements of molecules carry out mechanical processes on the molecular level, enabling precise movements and control at the nanoscale. One concept for a molecular machine is the Nanocar–a vehicle scaled down to the molecular level, as shown in Figure 1.3 The development of Nanocars through the manipulation of individual atoms and molecules pushes the realm of possibilities of mechanical miniaturization and nanotechnology. In this poster, we explore the synthesis of Nanocars with simple organic reactions to further expand the possibilities of molecular machinery.

Nanographene is a small section acquired from the larger aromatic graphene and used for its interesting OLED (organic light-emitting diode) properties. The highly aromatic nanographene has the ability to emit and absorb light at various wavelengths which, in turn, could generate cost-efficient methods to synthesize OLEDs. For this research of OUR term preliminary synthesis of the final nanographene product was conducted. The precursor is a complex di-naphthalene acetylene and was attempted to synthesized using a known synthesis.

To determine the minimum bactericidal concentration (MBC) and confirm minimum inhibitory concentration (MIC) of a benzothiophene derivative (#34) using the microdilution and
macrodilution assay against two gram-positive bacteria, including Staphylococcus aureus and Enterococcus faecalis.
● To explore the time and dose dependence bactericidal/bacteriostatic activity of the compound #34 using time kill assay.