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Presentation
The Effect of AICAR on Simvastatin Induced Myotoxicity
University of West Florida Libraries
Student Scholars Symposium and Faculty Research Showcase (University of West Florida, Pensacola, Florida, 04/16/2026)
Abstract
As the population ages, the rate of cholesterol skyrocketing increases, due to the loss of low-density lipoproteins (LDL) receptors, and is amplified by unhealthy lifestyle habits. Statin, a lipid-lowering medication, is prescribed to help reduce cholesterol by blocking 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) to produce LDLs, which reduces the risk of heart attacks. However, statins have risks, importantly causing muscle toxicity and muscle loss, due to mitochondrial cell damage and oxidative stress. This study will examine the underlying mechanisms of how skeletal muscle can proliferate and differentiate to identify damaged cells. Both Hannah Lee and Riley Hunt will use cell culture to grow myotubes (C2C12) and use fluorescent microscopy techniques to properly identify healthy and mature cells in skeletal muscle and differentiate the mitochondrial dysfunction and oxidative stress in cells.
Details
- Title
- The Effect of AICAR on Simvastatin Induced Myotoxicity
- Resource Type
- Presentation
- Event
- Student Scholars Symposium and Faculty Research Showcase (University of West Florida, Pensacola, Florida, 04/16/2026)
- Contributors
- Lee Youngil (Faculty Mentor)
- Publisher
- University of West Florida Libraries; Argo Scholar Commons
- Format
- pdf
- Copyright
- Permission granted to the University of West Florida Libraries by the author to digitize and/or display this information for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99381884859706600
- Academic Unit
- 2026 Student Scholars Symposium and Faculty Research Showcase; Usha Kundu, MD College of Health; Movement Sciences and Health
- Language
- English