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Efficacy of Preoperative versus Postoperative Prophylactic Antibiotic Administration in Reducing the Incidence of Infections
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Efficacy of Preoperative versus Postoperative Prophylactic Antibiotic Administration in Reducing the Incidence of Infections

Natalie Orr, Kailani Bermudes-Upshaw, Becca Compton and Marian Davis
University of West Florida Libraries
Integration of Evidence in Professional Nursing Practice Research Presentations, Research presentations (University of West Florida, Pensacola, Florida, 11/2025)
11/2025

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Abstract

Surgical site infections (SSIs) double the chance of patient mortality, increase the likelihood of needing time in the ICU by 60%, and make patients over 5 times more likely to be readmitted to the hospital (Canseco et al., 2021). SSIs effect roughly 158,000 patients annually in the United States. This uses significant hospital resources, costing health care systems between $3.5 and $10.1 billion dollars annually (Canseco et al., 2021). Current evidence based guidelines recommend beginning antibiotics within 1 hour of the first incision, stop antibiotics after the incision is closed, and to dose antibiotics based on the patient's weight to maximize antibiotic concentration and prevent infection (Calderwood et al., 2023). Despite these guidelines, many facilities are not adhering to these practices.
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