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Journal article
Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of alpha-Halo-alpha ',beta '-unsaturated Ketones
Organic letters, Vol.21(4), pp.1207-1211
02/15/2019
PMID: 30689391
Web of Science ID: WOS:000459366800076
Abstract
A vanadium-catalyzed coupling of allenylic alcohols with electrophilic halide sources to form alpha-halo-alpha',beta'-unsaturated ketones is described. The process proceeds through a metal enolate formed from the 1,3-transposition of an allenol that is initiated by a cheap and earth-abundant vanadium oxo catalyst. Fluorine, chlorine, and bromine electrophiles can be utilized, and the resulting products can give rise to the introduction of nitrogen, oxygen, sulfur, and iodine nucleophiles a to the ketone through substitution chemistry.
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Details
- Title
- Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of alpha-Halo-alpha ',beta '-unsaturated Ketones
- Publication Details
- Organic letters, Vol.21(4), pp.1207-1211
- Resource Type
- Journal article
- Publisher
- American Chemical Society
- Number of pages
- 5
- Grant note
- Franklin Veatch Memorial Award
- Copyright
- © 2019 American Chemical Society
- Identifiers
- WOS:000459366800076; 99381709174206600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English