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Journal article
Validation of an app-based portable spirometer in adolescents with asthma
The Journal of asthma, Vol.58(4), pp.497-504
04/01/2021
PMID: 31810411
Web of Science ID: WOS:000501688100001
Abstract
Objectives
Objective measurements of asthma impairment could aid teens in recognition of changes in asthma status over time. Ready access to a conventional spirometer is not realistic outside of the clinical setting. In this proof-of-concept study, we compared the performance of the VitalFlo mobile spirometer to the nSpire KoKo® sx1000 spirometer for accuracy in measuring Forced Expiratory Volume in one second (FEV1) and Forced Vital Capacity (FVC) in adolescents with asthma.
Methods
Two hundred forty pulmonary function measurements were collected from 48 adolescents with persistent asthma from the University of North Carolina’s pediatric allergy and pulmonology subspecialty clinics. Participants performed spirometry with the nSpireKoKo® sx1000 spirometer and the VitalFlo spirometer during their clinic visits. 119 simulated FVC maneuvers were conducted on both devices to standardize measurements. Pearson correlations, Bland-Altman procedure, and two-sample comparison tests were performed to assess the relationship between the two spirometers.
Results
VitalFlo measurements were significantly highly correlated with nSpireKoKo® spirometer values for FEV1, (r2=0.721, [95% CI, 0.749 ± 0.120], P < 0.001) and moderately for FVC (r2= 0.617, [95% CI, 0.640 ± 0.130], P < 0.001) measurements. There were no statistically significant differences of the mean FEV1 (M = 0.00764, SD = 0.364, t(59)=0.16, P = 0.87) and FVC measurements (M = 0.00261, SD = 0.565, t(59)=0.036, P = 0.97.) between the VitalFlo and nSpireKoKo® systems. Both devices demonstrated significantly high correlation when comparing the automated FVC (r2 = 0.997, [95% CI, 1.00 ± 0.00974], P < 0.001) measurements. Bland-Altman plots did not demonstrate significant bias between devices for both FEV1 (0.00764 L) and FVC (0.00261 L) measurements.
Conclusions
Lung function measurements from the VitalFlo mobile spirometer were comparable to a commercially-available spirometer commonly used in clinical settings. This validated app-based spirometer for home use has the potential to improve asthma self-management.
Details
- Title
- Validation of an app-based portable spirometer in adolescents with asthma
- Publication Details
- The Journal of asthma, Vol.58(4), pp.497-504
- Resource Type
- Journal article
- Publisher
- Taylor & Francis
- Number of pages
- 8
- Grant note
- American Academy of Allergy, Asthma and Immunology FoundationNSF ASSIST Nanosystems Award: EEC-1160483 NHLBI: 5 R01 HL135235 03 National Heart Lung and Blood Institute: R01HL135235
This work was supported by a grant from the American Academy of Allergy, Asthma and Immunology Foundation, NHLBI 5 R01 HL135235 03, and NSF ASSIST Nanosystems Award Number EEC-1160483.
- Copyright
- Rights managed by Taylor & Francis
- Identifiers
- WOS:000501688100001; 99381559029706600
- Academic Unit
- Usha Kundu, MD College of Health; Health Sciences and Administration
- Language
- English