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Journal article
Towards secondary prevention of early knee osteoarthritis
RMD Open: Rheumatic & musculoskeletal diseases, Vol.4(2), e000468
08/01/2018
PMCID: PMC6109947
PMID: 30167325
Web of Science ID: WOS:000442552300009
Abstract
Osteoarthritis (OA) of the knee is the most common arthritic disease, yet a convincing drug treatment is not available. The current narrative review focuses on integration of scientific evidence and professional experience to illustrate which management approaches can be taken for prototypical individual patient profiles with early knee OA. Animal models suggest that: (1) OA can progress even in the presence of fully recovered movement kinetics, kinematics and muscle activation patterns; (2) muscle weakness is an independent risk factor for the onset and possibly the rate of progression of knee OA; (3) onset and progression of OA are not related to body weight but appear to depend on the percentage of body fat. From studies in the human model, one could postulate that risk factors associated with progression of knee OA include genetic traits, preceding traumatic events, obesity, intensity of pain at baseline, static and dynamic joint malalignment and reduced muscle strength. Taken this into account, an individual can be identified as early knee OA at high risk for disease progression. A holistic patient-tailored management including education, supportive medication, weight loss, exercise therapy (aerobic, strengthening and neuromuscular) and behavioural approaches to improve self-management of early knee OA is discussed in individual prototypic patients. Secondary prevention of early knee OA provides a window of opportunity to slow down or even reverse the disease process. Yet, as the sheer number of patients early in the OA disease process is probably large, a more structured approach is needed to provide appropriate care depending on the patient’s individual risk profile.
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- Title
- Towards secondary prevention of early knee osteoarthritis
- Publication Details
- RMD Open: Rheumatic & musculoskeletal diseases, Vol.4(2), e000468
- Resource Type
- Journal article
- Publisher
- BMJ Group; United Kingdom
- Format
- link
- Number of pages
- 12
- Copyright
- This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
- Identifiers
- WOS:000442552300009; 99380504194306600
- Academic Unit
- Movement Sciences and Health; Usha Kundu, MD College of Health
- Language
- English