Timing is everything: towards classification criteria for early-stage symptomatic knee osteoarthritis
Armaghan Mahmoudian, Lauren K King, Jean W Liew, Qiuke Wang, C Thomas Appleton, Martin Englund, Ida K Haugen, L Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, …
Osteoarthritis and cartilage, Vol.In Press, Journal Pre-proof
More than three decades ago, the American College of Rheumatology introduced the first widely accepted classification criteria for knee osteoarthritis (OA). These criteria provided a standardized framework for identifying OA in research settings1. Since then, OA clinical trials have recruited participants based on these criteria, but have failed to identify disease-modifying interventions, raising the possibility that the ACR criteria do not capture patients early enough for interventions to restore joint homeostasis and slow or arrest the OA disease process2, 3. While there have been efforts to define symptomatic early-stage knee OA4, 5, 6, widely accepted and validated criteria do not exist.
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Timing is everything
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Osteoarthritis and cartilage, Vol.In Press, Journal Pre-proof