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Timing is everything: towards classification criteria for early-stage symptomatic knee osteoarthritis
Journal article   Peer reviewed

Timing is everything: towards classification criteria for early-stage symptomatic knee osteoarthritis

Armaghan Mahmoudian, Lauren K King, Jean W Liew, Qiuke Wang, C Thomas Appleton, Martin Englund, Ida K Haugen, L Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, …
Osteoarthritis and cartilage, Vol.In Press, Journal Pre-proof
03/02/2024
DOI: https://doi.org/10.1016/j.joca.2024.02.888
PMID: 38437945
Web of Science ID: WOS:001248210700001

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13 Times Cited - Web of Science

Abstract

More than three decades ago, the American College of Rheumatology introduced the first widely accepted classification criteria for knee osteoarthritis (OA). These criteria provided a standardized framework for identifying OA in research settings1. Since then, OA clinical trials have recruited participants based on these criteria, but have failed to identify disease-modifying interventions, raising the possibility that the ACR criteria do not capture patients early enough for interventions to restore joint homeostasis and slow or arrest the OA disease process2, 3. While there have been efforts to define symptomatic early-stage knee OA4, 5, 6, widely accepted and validated criteria do not exist.

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