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Journal article
Thiol-protease oxidation in age-related neuropathology
Free Radical Biology & Medicine, Vol.51(2), pp.282-288
51
2011
PMID: 21565267
Web of Science ID: WOS:000292352500005
Abstract
Increased oxidative stress is a hallmark of every major neurodegenerative disease that has been studied. Numerous biomarkers of oxidative stress have been found, indicating that waves of oxidation had, at one time or another, overwhelmed antioxidant defenses, leaving behind a host of oxidized DNA, lipids, and proteins in their path. Although some level of oxidation may be beneficial, perhaps mediated by a hormetic response, the extent and types of oxidation detected in neuropathological states would suggest that oxidative stress contributes to a loss of homeostasis and cellular dysfunction. Although there are many targets of oxidants, this review emphasizes protein oxidation with a focus on an important group of redox-sensitive enzymes, the thiol-proteases. Both the direct and the indirect effects of oxidation and their potential importance in neurodegeneration are considered.
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Details
- Title
- Thiol-protease oxidation in age-related neuropathology
- Publication Details
- Free Radical Biology & Medicine, Vol.51(2), pp.282-288
- Resource Type
- Journal article
- Publisher
- Elsevier Inc.; United States
- Series
- 51
- Identifiers
- WOS:000292352500005; 99380090608306600
- Academic Unit
- Mathematics and Statistics; Hal Marcus College of Science and Engineering ; Biology
- Language
- English