Metrics
27 Record Views
Journal article
Synthesis of pyrrolo-[2,1-j]quinolone framework via intramolecular electrophilic ipso-cyclization
Tetrahedron letters, Vol.54(11), pp.1344-1347
03/13/2013
Web of Science ID: WOS:000315306900003
Abstract
The challenging pyrrolo-12,1-j]quinolone core structure has been synthesized from N-(alkynoyl)-6-methoxytetrahydroquinoline in good yields using electrophilic cyclization as the key step. These reactions require simple starting materials and mild reaction conditions. In addition, we have demonstrated that the iodine moiety, which could be easily introduced in the final step, is very useful for further functionalization by employing various palladium-catalyzed cross-coupling reactions. (C) 2012 Elsevier Ltd. All rights reserved.
Related links
Details
- Title
- Synthesis of pyrrolo-[2,1-j]quinolone framework via intramolecular electrophilic ipso-cyclization
- Publication Details
- Tetrahedron letters, Vol.54(11), pp.1344-1347
- Resource Type
- Journal article
- Publisher
- Elsevier
- Grant note
- 1039659 / National Science Foundation; National Science Foundation (NSF) 1039659 / Direct For Mathematical & Physical Scien; National Science Foundation (NSF); NSF - Directorate for Mathematical & Physical Sciences (MPS) Bard Summer Research Institute
- Copyright
- Copyright © 2012 Elsevier Ltd. All rights reserved.
- Identifiers
- WOS:000315306900003; 99380480677206600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English