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Journal article
Synthesis of 3-Halo-7-azaindoles through a 5-endo -dig Electrophilic Cyclization Reaction
Synlett, Vol.30(10), pp.1246-1252
06/01/2019
Web of Science ID: WOS:000471234600022
Abstract
Biologically useful 7-azaindoles were synthesized by electrophilic cyclization of 3-alkynyl- N , N -dimethylpyridine-2-amines with molecular iodine. By this simple atom-economical approach under ambient reaction conditions, a library of interesting 3-iodo-7-azaindoles were synthesized in high yields. To synthesize the corresponding 3-bromo- and 3-chloro-7-azaindoles, an environmentally benign copper-mediated cyclization was employed, with inexpensive, nontoxic, and noncorrosive sodium chloride and sodium bromide as the sources of chlorine and bromine, respectively.
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Details
- Title
- Synthesis of 3-Halo-7-azaindoles through a 5-endo -dig Electrophilic Cyclization Reaction
- Publication Details
- Synlett, Vol.30(10), pp.1246-1252
- Resource Type
- Journal article
- Publisher
- Georg Thieme Verlag; 0936-5214
- Number of pages
- 7
- Grant note
- University of West Florida (UWF) 23248 / Research Corporation for Science Advancement for a Cottrell College Science Award 1T34GM110517-01 / National Institute of General Medical Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Office of Undergraduate Research UWF's Office of Research and Sponsored Programs
- Copyright
- © Georg Thieme Verlag Stuttgart · New York
- Identifiers
- WOS:000471234600022; 99380480796006600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Chemistry
- Language
- English