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Journal article
Spatial and space-time clusters of brain tumor and CNS incidence and mortality in the contiguous USA: 2000-2014
Social Sciences & Humanities Open, Vol.4
4
2021
Abstract
Objective: Investigate geographical variations in brain/central nervous system (CNS) cancer incidence and mortality, and test associations between covariates and brain/CNS cancer for the years 2000–2014 in the contiguous USA.
Methods: The disease surveillance software (SaTScanTM) was used to measure observable geographical variation in brain/CNS cancer incidence and mortality rates and identify and test spatial and space-time clusters with elevated relative risk. The analysis was done with age-adjusted brain/CNS cancer mortality and incidence counts data, including ICD codes C710–C719, C379, C740–C749, and C750–C759. The cancer data were then adjusted for covariates or risk factors, such as obesity, smoking, poverty, race, arsenic, air pollution, land pollution, water pollution, gender, health insurance, diabetes, glyphosate, superfund site density, and proximity to nuclear power plants.
Results: Several significant spatial clusters of brain/CNS cancer exist for incidence in the Northeast and the Northwest, while spatial mortality clusters cover additional parts of the US. There also exist several significant space-time clusters for incidence and mortality.
Conclusions: There exist significant and non-random brain/CNS cancer incidence and mortality clusters after adjusting for multiple covariates or risk factors. The thirteen covariates studied can assist in a better understanding of possible associations in geographical areas where the incidence or mortality rates are higher than expected. There is a significant association between several of the studied risk factors and the incidence rates of brain/CNS cancers, and the mortality rates. These results have the potential to provide a scientific framework
that is based on surveillance, allowing health agencies to intervene to try to reduce the elevated rates of brain/CNS cancer in some parts of the contiguous US.
Details
- Title
- Spatial and space-time clusters of brain tumor and CNS incidence and mortality in the contiguous USA
- Publication Details
- Social Sciences & Humanities Open, Vol.4
- Resource Type
- Journal article
- Publisher
- Elsevier Ltd; United Kingdom
- Series
- 4
- Copyright
- © 2021 The Authors. Permission granted to the University of West Florida Libraries to digitize and/or display this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380090871306600
- Academic Unit
- Mathematics and Statistics; Hal Marcus College of Science and Engineering ; Biology
- Language
- English