Journal article
Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants
Scientific reports, Vol.14(1), 12609
06/01/2024
PMID: 38824194
Web of Science ID: WOS:001237934300033
Abstract
Peripheral artery disease (PAD) is characterized by varying severity of arterial stenosis, exercise induced claudication, malperfused tissue precluding normal healing and skeletal muscle dysfunction. Revascularization interventions improve circulation, but post-reperfusion changes within the skeletal muscle are not well characterized. This study investigates if revascularization enhanced hemodynamics increases walking performance with concurrent improvement of mitochondrial function and reverses abnormal skeletal muscle morphological features that develop with PAD. Fifty-eight patients completed walking performance testing and muscle biopsy before and 6 months after revascularization procedures. Muscle fiber morphology, desmin structure, and mitochondria respiration assessments before and after the revascularization were evaluated. Revascularization improved limb hemodynamics, walking function, and muscle morphology. Qualitatively not all participants recovered normal structural architecture of desmin in the myopathic myofibers after revascularization. Heterogenous responses in the recovery of desmin structure following revascularization may be caused by other underlying factors not reversed with hemodynamic improvements. Revascularization interventions clinically improve patient walking ability and can reverse the multiple subcellular functional and structural abnormalities in muscle cells. Further study is needed to characterize desmin structural remodeling with improvements in skeletal muscle morphology and function.
Details
- Title
- Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants
- Publication Details
- Scientific reports, Vol.14(1), 12609
- Resource Type
- Journal article
- Publisher
- Nature Publishing Group
- Grant note
- R01AG064420 / NIA NIH HHS R01 AG064420 / NIA NIH HHS
- Copyright
- © 2024, The Author(s)
- Identifiers
- WOS:001237934300033; 99380580795506600
- Academic Unit
- Usha Kundu, MD College of Health; Public Health
- Language
- English