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Journal article
Site-selective C–H functionalization in a cyclodextrin metal-organic framework
Chem, Vol.10(1), pp.234-249
01/2024
Web of Science ID: WOS:001156301000001
Abstract
Billions of years of evolution have honed nature’s extraordinary capacity in promoting site-selective functionalization of C(sp3)–H bonds in complex molecules. Central to this incredible proficiency is the effect of confinement incurred by enzymes’ active sites, which pre-organize substrates in desired co-conformations prior to their selective transformations. The fact that C(sp3)–H bonds with negligible stereoelectronic differences can be differentiated at an Ångström level during enzymatic catalysis means that precise control of site selectivities in C(sp3)–H functionalization can in principle be achieved by tailoring the cavity sizes, geometries, and stereoelectronic environments of artificial receptors. Given the importance of late-stage functionalization in drug development, there is every reason to believe that confinement, among other strategies, will become an increasingly important tool for tackling challenges in the selective editing of C(sp3)–H bonds in complex settings.
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Details
- Title
- Site-selective C–H functionalization in a cyclodextrin metal-organic framework
- Publication Details
- Chem, Vol.10(1), pp.234-249
- Resource Type
- Journal article
- Publisher
- Cell Press; United States
- Copyright
- © 2023 Elsevier Inc.
- Identifiers
- WOS:001156301000001; 99380496196206600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English