Journal article
Similar Responses in the Akt/Protein Kinase B Signaling Pathway Following Different Lower-Body Exercise Volumes in Recreationally Active Men
Journal of strength and conditioning research, Vol.37(5), pp.1034-1041
05/01/2023
PMID: 36727994
Web of Science ID: WOS:000978967000014
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Abstract
Pearson, JR, Moodie, N, Stout, KW, Hawkins, WC, Matuszek, M, Graham, ZA, Siedlik, JA, Vardiman, JP, and Gallagher, PM. Similar responses in the Akt/protein kinase B (PKB) signaling pathway after different lower-body exercise volumes in recreationally active men. J Strength Cond Res 37(5): 1034-1041, 2023-This project examined the differences between a single set (SS) compared to multiple sets (MS) of resistance exercise on the Akt/protein kinase B (PKB) signaling pathway, the expression of insulin-like growth factor-1 (IGF-1), and the receptor for IGF-1 (IGF-1R) to better understand the types of resistance training protocols that are most beneficial in stimulating the muscle hypertrophic response. Sixteen healthy men were randomly selected into 2 groups of 8. Subjects in each group received 3 biopsies: (a) before exercise, (b) 15 minutes postexercise, and (c) 180 minutes postexercise. Subjects in the SS group performed 1 set of leg press to failure at 80% of their predetermined 1 repetition maximum (1RM). Subjects in the MS group performed 2 sets of 10 repetitions and 1 set to failure at 80% of their predetermined 1RM, with 3 minutes of rest between each set. Our results indicated no group x time interactions in the concentration of Akt signaling proteins. Furthermore, there were no group x time interactions in IGF-1 or IGF-1R expression. However, phosphorylated 4E-binding protein 1 levels increased 150% from pre to 180 minutes post (p = 0.005). In addition, there was a significantly greater increase in IGF-1R expression in the SS group compared with the MS group (7.99 +/- 10.07 vs. 4.41 +/- 6.28; p = 0.026). Collectively, we found that a SS of resistance training evokes a similar acute Akt/PKB pathway response as MS in recreationally active men.
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Details
- Title
- Similar Responses in the Akt/Protein Kinase B Signaling Pathway Following Different Lower-Body Exercise Volumes in Recreationally Active Men
- Publication Details
- Journal of strength and conditioning research, Vol.37(5), pp.1034-1041
- Resource Type
- Journal article
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- ACSM/NASA Space Physiology Research Grant University General Research Fund grant
- Copyright
- © 2023 National Strength and Conditioning Association
- Identifiers
- WOS:000978967000014; 99380570796506600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Biology
- Language
- English