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Journal article
Screening for diabetes: Sensitivity and positive predictive value of risk factor total
Clinical Laboratory Science, Vol.18(4), pp.221-225
18
2005
PMID: 16315739
Abstract
OBJECTIVE: Screening for diabetes is recommended for individuals ≥45 years of age, or earlier if they manifest ≥ one specific risk factors. This study examined the sensitivity and positive predictive value (PPV) of risk factor total for identifying individuals with diabetes and prediabetes.
DESIGN: Subjects were interviewed to assess the presence of risk factors. Fasting plasma glucose levels were obtained.
SETTING: The study occurred at a health fair in Greensburg, PA.
PATIENTS: Six hundred sixty-one Caucasians between the ages of 19 and 100.
RESULTS: Using the criterion of screening individuals with ≥ one risk factors detected 100% of both diabetics and prediabetics. This dropped to 91.2% when screening individuals with > two factors. The PPV of the risk factor total was poor (80% of individuals with a total of four factors were not diabetic). The ability of the risk factor total to predict individuals with impaired glucose metabolism (prediabetics + diabetics) was considerably better, and increased almost linearly with the risk factor total. Of the subjects with normal glucose values, the mean glucose increased as the risk factor total increased.
CONCLUSION: While the sensitivity of using ≥ one risk factor as an algorithm to screen is 100% for identifying diabetics, the PPV of risk factor analysis for identifying diabetics is poor. The same algorithm works well to identify at-risk individuals, presumably allowing early intervention and education.
Details
- Title
- Screening for diabetes
- Publication Details
- Clinical Laboratory Science, Vol.18(4), pp.221-225
- Resource Type
- Journal article
- Publisher
- American Society for Clinical Laboratory Science; United States
- Series
- 18
- Copyright
- Permission granted to the University of West Florida Libraries to digitize and/or display this information for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380090891606600
- Academic Unit
- Medical Laboratory Sciences
- Language
- English