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Rethinking early-stage knee osteoarthritis beyond radiography
Journal article   Peer reviewed

Rethinking early-stage knee osteoarthritis beyond radiography

Armaghan Mahmoudian and Ida K Haugen
Nature reviews. Rheumatology, Vol.online ahead of print
05/27/2026
PMID: 42203902
Web of Science ID: WOS:001778474900001

Abstract

Symptomatic knee osteoarthritis Health Care Magnetic Resonance Imaging Osteoarthritis
Symptomatic knee osteoarthritis at an early structural stage could provide a window of opportunity for intervention. Symptomatic knees without definite radiographic osteoarthritis can already show structural joint changes detectable on MRI; however, the greater sensitivity of MRI must be balanced against the risks of overdiagnosis and overtreatment. Refers to Drummen, S. J. J. et al. The associations between a diagnosis of early-stage knee osteoarthritis and the presence of MRI abnormalities in knees without radiographic osteoarthritis: data from 1513 knees of the osteoarthritis initiative. Osteoarthritis Cartilage https://doi.org/10.1016/j.joca.2026.02.015 (2026).

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