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Journal article
Regulation of autophagy by metabolic and stress signaling pathways in the heart
Journal of Cardiovascular Pharmacology, Vol.60, pp.118-124
60
2012
PMCID: PMC3419780
PMID: 22472907
Web of Science ID: WOS:000308006500003
Abstract
Autophagy is an essential process for the maintenance of cellular homeostasis in the heart under both normal and stress conditions. Autophagy is a key degradation pathway and acts as a quality control sensor. It protects myocytes from cytotoxic protein aggregates and dysfunctional organelles by quickly clearing them from cell. It also responds to changes in energy demand and mechanical stressors to maintain contractile function. The autophagic-lysosomal pathway responds to serum starvation to ensure that the cell maintains its metabolism and energy levels when nutrients run low. In contrast, excessive activation of autophagy is detrimental to cells and contributes to development of pathological conditions. A number of signaling pathways and proteins regulate autophagy. These include the AMPK/mTOR pathway, FoxO transcription factors, Sirt1, oxidative stress, Bcl-2 family proteins, and the E3 ubiquitin ligase Parkin. In this review, we will discuss how this diverse cast of characters regulates the important autophagic process in the myocardium.
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Details
- Title
- Regulation of autophagy by metabolic and stress signaling pathways in the heart
- Publication Details
- Journal of Cardiovascular Pharmacology, Vol.60, pp.118-124
- Resource Type
- Journal article
- Publisher
- Lippincott Williams & Wilkins; United States
- Series
- 60
- Copyright
- © 2012 Lippincott Williams
- Identifiers
- WOS:000308006500003; 99380090769506600
- Academic Unit
- Movement Sciences and Health; Usha Kundu, MD College of Health
- Language
- English