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Journal article
Redox regulation of cysteine-dependent enzymes in neurodegeneration
International Journal of Cell Biology, Vol.2012
2012
2012
PMCID: PMC3398591
PMID: 22829832
Abstract
Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to oxidant-induced modifications that alter their function. Results of clinical trials based on the oxidative-stress theory have been mixed, though data continues to indicate that prevention of high levels of oxidative stress is beneficial for health and increases longevity. Due to the highly reactive nature of the sulfhydryl group, the focus of this paper is on the impact of oxidative stress on cysteine-dependent enzymes and how oxidative stress may contribute to neurological dysfunction through this selected group of proteins.
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- Title
- Redox regulation of cysteine-dependent enzymes in neurodegeneration
- Publication Details
- International Journal of Cell Biology, Vol.2012
- Resource Type
- Journal article
- Publisher
- Hindawi Limited; United Kingdom
- Series
- 2012
- Copyright
- 2012 R. P. Guttmann and T. J. Powell. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Identifiers
- 99380090873706600
- Academic Unit
- Biology; Hal Marcus College of Science and Engineering
- Language
- English