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Preliminary study of the effects of age and type-2 diabetes on the release of interleukin (IL)-6, IL-10, TNF-Alpha, and cortisol in response to acute exercise
Journal article   Peer reviewed

Preliminary study of the effects of age and type-2 diabetes on the release of interleukin (IL)-6, IL-10, TNF-Alpha, and cortisol in response to acute exercise

Ludmila Cosio-Lima, Petra Schuler, Katy Reynolds, Lemuel Taylor, Gordon Kellog, Jill Cerney, Tabitha Hodges and Paul Leblanc
Journal of Exercise Physiology - Online, Vol.11, pp.33-41
11
2008

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Abstract

The immune response to exercise results in the release of inflammatory markers. This study examined the effects of age and type-2 diabetes on cytokine response following an acute bout of exercise. Five older type-2 diabetics (OD) (mean age 82±3 years), 5 non-diabetic (79±6 years) older adults (OND), and 5 young healthy (YH) (26±3years) control subjects were studied before and following a sub-maximal incremental treadmill test. Venous blood samples were collected immediately pre- and 5 minutes post-exercise, and plasma was analyzed for interleukin (IL)-6, IL -10, tumor necrosis factor-a (TNF-a), C–reactive protein (CRP), and cortisol levels . Cortisol levels were significantly elevated postexercise (p<0.05) for all participants suggesting a sufficient exercise stimulus (>60%HRR). A significant main effect for group was found for IL-6 (p<0.05) with post-hoc tests suggesting significantly higher levels in the older diabetic group (OD) compared to the young controls (YH). No significant group by time interaction was found for any of the variables studied. Present study findings suggest that age, rather than the presence of diabetes, affected resting plasma IL -6 levels. Furthermore, neither age nor diabetes influenced cytokine responses to an acute bout of exercise.

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