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Journal article
Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection
The journal of physiological sciences : JPS, Vol.67, pp.639-654
67
2017
PMCID: PMC5684252
PMID: 28685325
Web of Science ID: WOS:000413012700001
Abstract
Cardiac myocytes are terminally differentiated cells and possess extremely limited regenerative capacity; therefore, preservation of mature cardiac myocytes throughout the individual’s entire life span contributes substantially to healthy living. Autophagy, a lysosomedependent
cellular catabolic process, is essential for normal cardiac function and mitochondria maintenance. Therefore, it may be reasonable to hypothesize that if endurance exercise promotes cardiac autophagy and mitochondrial autophagy or mitophagy, exercise-induced cardiac autophagy (EICA) or exercise-induced cardiac mitophagy (EICM) may confer propitious cellular environment and thus protect the heart against detrimental stresses, such as an ischemia–reperfusion (I/R) injury. However, although the body of evidence supporting EICA and EICM is growing, the molecular mechanisms of EICA and EICM and their possible roles in cardioprotection against an I/R injury are poorly understood. Here, we introduce the general mechanisms of autophagy in an attempt to integrate potential molecular pathways of EICA and EICM and also highlight a potential insight into EICA and EICM in cardioprotection against an I/R insult.
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Details
- Title
- Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection
- Publication Details
- The journal of physiological sciences : JPS, Vol.67, pp.639-654
- Resource Type
- Journal article
- Publisher
- Springer Japan; Tokyo, Japan
- Series
- 67
- Copyright
- The Physiological Society of Japan and Springer Japan KK 2017
- Identifiers
- WOS:000413012700001; 99380090641806600
- Academic Unit
- Usha Kundu, MD College of Health; Movement Sciences and Health
- Language
- English