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Journal article
Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization
Physica medica, Vol.103, pp.127-137
11/2022
PMID: 36302279
Web of Science ID: WOS:000880766300002
Abstract
FLASH radiation therapy is a novel technique combining ultra-high dose rates (UHDR) with very short treatment times to strongly decrease normal tissue toxicity while preserving the anti-tumoral effect. However, the radiobiological mechanisms and exact conditions for obtaining the FLASH-effect are still under investigation. There are strong indications that parameters defining the beam structure, such as dose per pulse, instantaneous dose rate and pulse repetition frequency (PRF) are of importance. UHDR irradiations therefore come with dosimetric challenges, including both dose assessment and temporal ones. In this work, a first characterization of 6 real-time point scintillating dosimeters with 5 phosphors (AlO:C,Mg; YO:Eu; AlO:C; (C38H34P)MnBr and (C38H34P)MnCl, was performed in an UHDR pulsed electron beam. The dose rate independence of the calibration was tested by calibrating the detector at conventional and UHDR. Dose rate dependence was observed, however, further investigation, including intermediate dose rates, is needed. Linearity of the response with dose was tested by varying the number of pulses and a linearity with R 0.9989 was observed up to at least 200 Gy. Dose per pulse linearity was investigated by variation of the pulse length and SSD. All point scintillators showed saturation effects up to some extent and the instantaneous dose rate dependence was confirmed. A PRF dependence was observed for the AlO:C,Mg and AlO:C- based point scintillators. This was expected as the luminescence decay time of these materials exceeds the inter-pulse time.
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Details
- Title
- Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy
- Publication Details
- Physica medica, Vol.103, pp.127-137
- Resource Type
- Journal article
- Publisher
- Elsevier Ltd; London
- Number of pages
- 11
- Grant note
- VLAIO via the Flanders.HealthTech call: HBC.2021.0946 EMPIR programme - FSU GAP Commercialization Investment ProgramSordina IORT TechnologiesFSU GAP Commercialization Investment Program
This work was supported by VLAIO via the Flanders.HealthTech call [HBC.2021.0946]. SCK CEN and Iridium Network are also non-funded collaborators to the 18HLT04 UHDpulse project which received funding from the EMPIR programme. UHDR research in the Iridium Network is partially funded by Sordina IORT Technologies S.p.A.. TBS and BM thank the support from the FSU GAP Commercialization Investment Program.
- Copyright
- © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.
- Identifiers
- WOS:000880766300002; 99381437831006600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English