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Journal article
Pesticide Residue Intake From Fruit and Vegetable Consumption and Risk of Uterine Fibroids
Current developments in nutrition, Vol.5(Supplement_2), pp.1033-1033
06/2021
Abstract
Dietary factors may play a role in uterine fibroids etiology due to their potential to modify endogenous hormones and their inflammatory effects – these processes may be influenced by food contaminants including pesticides. We sought to examine the association between pesticide residue intake from consumption of fruits and vegetables and risk of ultrasound or hysterectomy-confirmed fibroids.
A prospective cohort study using data collected from 52,982 premenopausal women from 1999–2009 in the Nurses’ Health Study II. Every four years, diet was assessed with a validated food frequency questionnaire. We classified fruits and vegetables into high- or low-pesticide-residues using a validated method based on surveillance data from the U.S. Department of Agriculture. Multivariable Cox proportional hazards models were used to calculate RR and 95% CIs for the association between high- and low-pesticide-residue fruit and vegetable intake and fibroids.
During 10 years of follow-up (median age at baseline 42 years), 4,285 incident cases of ultrasound or hysterectomy-confirmed fibroids were reported. No association was observed between intake of high-pesticide-residue (RR for 5th vs 1st quintile = 0.91; 95% CI = 0.80–1.03; ptrend = 0.12) nor the low-pesticide-residue (RR for 5th vs 1st quintile = 1.01; 95% CI = 0.88–1.14; ptrend = 0.84) fruits and vegetables and fibroids.
No clear associations were observed between intake of high- or low-pesticide-residue fruits and vegetables and risk of uterine fibroids. These results suggest that pesticide residues on fruits and vegetables are not strong contributors to fibroid risk among women in their 30s, 40s, and 50s. Additional studies examining an exposure window more proximal to fibroid initiation among younger women and assessing class specific pesticides are needed.
National Institutes of Health.
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Details
- Title
- Pesticide Residue Intake From Fruit and Vegetable Consumption and Risk of Uterine Fibroids
- Publication Details
- Current developments in nutrition, Vol.5(Supplement_2), pp.1033-1033
- Resource Type
- Journal article
- Publisher
- Elsevier Inc
- Copyright
- © 2021 American Society for Nutrition.
- Identifiers
- 99380571969106600
- Academic Unit
- Public Health; Usha Kundu, MD College of Health
- Language
- English