Journal article
Modular access to functionalized 5-8-5 fused ring systems via a photoinduced cycloisomerization reaction
Chemical science (Cambridge), Vol.9(24), pp.5389-5393
06/28/2018
PMID: 30009010
Web of Science ID: WOS:000436027800011
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Abstract
A 5-8-5 carbocyclic ring system forms the core of over 30 distinct natural products. Several members of this family have gained attention for their diverse activity in cell culture. In these cases, biological function is mediated by the arrangement of substituents around a conserved 5-8-5 nucleus. Despite the potential applications of this privileged substructure in medicinal chemistry, modular strategies for its assembly are underdeveloped. Herein, we describe a cycloisomerization reaction that forms the 5-8-5 framework directly. This strategy uniquely allows access to gram quantities of this valuable scaffold in four steps.
Details
- Title
- Modular access to functionalized 5-8-5 fused ring systems via a photoinduced cycloisomerization reaction
- Publication Details
- Chemical science (Cambridge), Vol.9(24), pp.5389-5393
- Resource Type
- Journal article
- Publisher
- Royal Society of Chemistry
- Grant note
- S10 OD021758 / NIH HHS R01 GM125926 / NIGMS NIH HHS
- Copyright
- © the author(s)
- Identifiers
- WOS:000436027800011; 99381856817506600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English