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Journal article
Mesenchymal Stem/Stromal Cells Microencapsulation for Cell Therapy
Cells (Basel, Switzerland), Vol.14(3), p.149
02/01/2025
PMID: 39936941
Web of Science ID: WOS:001418339000001
Abstract
Cell microencapsulation is one of the most studied strategies to overcome the challenges associated with the implementation of mesenchymal stem/stromal cells (MSCs) in vivo. This approach isolates/shields donor MSCs from the host immune system using a semipermeable membrane that allows for the diffusion of gases, nutrients, and therapeutics, but not host immune cells. As a result, microencapsulated MSCs survive and engraft better after infusion, and they can be delivered specifically to the targeted site. Additionally, microencapsulation enables the co-culture of MSCs with different types of cells in a three-dimensional (3D) environment, allowing for better cellular interaction. Alginate, collagen, and cellulose are the most popular materials, and air jet extrusion, microfluidics, and emulsion are the most used techniques for MSC cell encapsulation in the literature. These materials and techniques differ in the size range of the resultant microcapsules and their compatibility with the applied materials. This review discusses various materials and techniques used for the microencapsulation of MSCs. We also shed light on the recent findings in this field, the advantages and drawbacks of using encapsulated MSCs, and the in vivo translation of the microencapsulated MSCs in cell therapy.
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- Title
- Mesenchymal Stem/Stromal Cells Microencapsulation for Cell Therapy
- Publication Details
- Cells (Basel, Switzerland), Vol.14(3), p.149
- Resource Type
- Journal article
- Publisher
- MDPI
- Grant note
- 1R01DK105183, DK123094, DK118529, DK125464 / NIDDK NIH HHS R01 DK105183 / NIDDK NIH HHS R01 DK123094 / NIDDK NIH HHS R01 DK125464 / NIDDK NIH HHS R01 DK118529 / NIDDK NIH HHS I01 BX004536 / BLRD VA I01 CX002516 / CSRD VA
- Copyright
- © the author(s)
- Identifiers
- WOS:001418339000001; 99381814468006600
- Academic Unit
- Biology; Hal Marcus College of Science and Engineering
- Language
- English