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Journal article
Iodocyclization in Aqueous Media and Supramolecular Reaction Control Using Water-Soluble Hosts
ACS Omega, Vol.4(18), pp.17830-17836
10/29/2019
PMCID: PMC6822118
PMID: 31681890
Web of Science ID: WOS:000493751800024
Abstract
Iodocyclization of 2-alkynylanisoles is an efficient route for synthesizing substituted benzofurans. Reaction efficiency with copper(II) sulfate and sodium iodide in an aqueous slurry under mild conditions is a manifold higher than in organic solvents. Water-soluble hosts of the cyclodextrin family solubilize the compounds in aqueous media and affect the reaction efficiency through conformation control and steric interactions. Computational chemistry and spectral titration provide information on the host-guest complex structure and insight into the mechanistic basis of the observed effects.
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- Title
- Iodocyclization in Aqueous Media and Supramolecular Reaction Control Using Water-Soluble Hosts
- Publication Details
- ACS Omega, Vol.4(18), pp.17830-17836
- Resource Type
- Journal article
- Publisher
- American Chemical Society (ACS); United States
- Format
- link
- Number of pages
- 7
- Grant note
- University of West Florida (UWF) 54862-UR4 / ACS-Petroleum Research Fund; American Chemical Society; American Cancer Society UWF Office of Undergraduate Research T34GM110517 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 23248 / Research Corporation for Science Advancement for the Cottrell College Science Award UWF Office of Research and Sponsored Programs UNK's Office of Sponsored Programs 1T34GM110517-01 / National Institute of General Medical Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Copyright
- Copyright © 2019 American Chemical Society
- Identifiers
- WOS:000493751800024; 99380480677706600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Chemistry
- Language
- English