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Journal article
Highly Chemoselective Deprotection of the 2,2,2-Trichloroethoxycarbonyl (Troc) Protecting Group
Organic letters, Vol.20(24), pp.8043-8046
12/21/2018
PMID: 30511873
Web of Science ID: WOS:000454567800067
Abstract
Nonreducing, pH -neutral conditions for the selective cleavage of the 2,2,2-trichloroethoxycarbonyl (Troc) protecting group are reported. Using trimethyltin hydroxide in 1,2-dichloroethane, Troc-protected alcohols, thiols, and amines can be selectively unmasked in the presence of various functionalities that are incompatible with the reducing conditions traditionally used to remove the Troc group. This mild deprotection protocol tolerates a variety of other hydrolytically sensitive and acid/base-sensitive moieties as well.
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Details
- Title
- Highly Chemoselective Deprotection of the 2,2,2-Trichloroethoxycarbonyl (Troc) Protecting Group
- Publication Details
- Organic letters, Vol.20(24), pp.8043-8046
- Resource Type
- Journal article
- Publisher
- American Chemical Society
- Number of pages
- 4
- Grant note
- Franklin Veatch Memorial Award Fellowship
- Copyright
- © 2018 American Chemical Society
- Identifiers
- WOS:000454567800067; 99381709285606600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English