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Journal article
HbA1c does not always estimate average glucose
Clinical Laboratory Science, Vol.24, pp.71-77
24
2011
PMID: 21657138
Abstract
Hemoglobin A1c (HbA1c) testing can be inaccurate in persons with elevated amounts of Hemoglobin F, or with abnormal hemoglobins found in sickle cell trait, HbC trait and HbE trait. These variants are more prevalent in African and Asian Americans, the same demographic that has an increased risk of diabetes. Variant hemoglobins might cause a false increase or decrease in HbA1c, depending on methodology and manufacturer. Case studies of two African American patients, one with and one without variant hemoglobins, are presented. The major methods used to assay HbA1c, immunoassay, HPLC and boronate affinity are described, and compared for their ability to detect variant hemoglobins. An algorithm is proposed to test new patients using the HPLC method to identify or rule out the presence of the most common variant hemoglobins. Patients with variant hemoglobins can subsequently be assigned to HbA1c methods proven
to be accurate in the presence of those hemoglobins.
Details
- Title
- HbA1c does not always estimate average glucose
- Publication Details
- Clinical Laboratory Science, Vol.24, pp.71-77
- Resource Type
- Journal article
- Publisher
- American Society for Clinical Laboratory Science; United States
- Series
- 24
- Copyright
- Permission granted to the University of West Florida Libraries to digitize and/or display this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380090788506600
- Academic Unit
- Medical Laboratory Sciences; Usha Kundu, MD College of Health
- Language
- English