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Journal article
Green synthesis of halogenated thiophenes, selenophenes and benzo[b] selenophenes using sodium halides as a source of electrophilic halogens
Tetrahedron letters, Vol.58(7), pp.638-641
02/15/2017
PMCID: PMC5741090
PMID: 29277842
Web of Science ID: WOS:000393936800010
Abstract
Herein, we report the first synthesis of chlorinated benzo[b]selenophenes via environmentally friendly electrophilic chlorocyclization reaction using "table salt" as a source of "electrophilic chlorine" and ethanol as a solvent. In addition, the synthesis of diverse halogenated heterocycles, including 3-chloro, 3-bromo and 3-iodo thiophenes, selenophenes, and benzo[b]selenophenes was successfully accomplished under the same environmentally benign reaction conditions. This methodology has several advantages over other previously reported reactions as it employs simple starting compounds, an environmentally friendly solvent, ethanol, and non-toxic inorganic reagents under mild reaction conditions, resulting in the high product yields. (C) 2017 Elsevier Ltd. All rights reserved.
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Details
- Title
- Green synthesis of halogenated thiophenes, selenophenes and benzo[b] selenophenes using sodium halides as a source of electrophilic halogens
- Publication Details
- Tetrahedron letters, Vol.58(7), pp.638-641
- Resource Type
- Journal article
- Publisher
- Elsevier; United Kingdom
- Number of pages
- 4
- Grant note
- University of West Florida (UWF) UWF's Office of Research 23248 / Research Corporation for Science Advancement 1T34GM110517-01 / National Institute of General Medical Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) T34GM110517 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Copyright
- © 2017 Elsevier Ltd. All rights reserved.
- Identifiers
- WOS:000393936800010; 99380480796206600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Chemistry
- Language
- English