Journal article
Genital Powder Use and Risk of Epithelial Ovarian Cancer in the Ovarian Cancer in Women of African Ancestry Consortium
Cancer epidemiology, biomarkers & prevention, Vol.30(9), pp.1660-1668
09/01/2021
PMID: 34155063
Web of Science ID: WOS:000696386200010
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Abstract
Genital powder use is more common among African-American women; however, studies of genital powder use and ovarian cancer risk have been conducted predominantly in White populations, and histotype-specific analyses among African-American populations are limited.
We used data from five studies in the Ovarian Cancer in Women of African Ancestry consortium. Participants included 620 African-American cases, 1,146 African-American controls, 2,800 White cases, and 6,735 White controls who answered questions on genital powder use prior to 2014. The association between genital powder use and ovarian cancer risk by race was estimated using logistic regression.
The prevalence of ever genital powder use for cases was 35.8% among African-American women and 29.5% among White women. Ever use of genital powder was associated with higher odds of ovarian cancer among African-American women [OR = 1.22; 95% confidence interval (CI) = 0.97-1.53] and White women (OR = 1.36; 95% CI = 1.19-1.57). In African-American women, the positive association with risk was more pronounced among high-grade serous tumors (OR = 1.31; 95% CI = 1.01-1.71) than with all other histotypes (OR = 1.05; 95% CI = 0.75-1.47). In White women, a significant association was observed irrespective of histotype (OR = 1.33; 95% CI = 1.12-1.56 and OR = 1.38; 95% CI = 1.15-1.66, respectively).
While genital powder use was more prevalent among African-American women, the associations between genital powder use and ovarian cancer risk were similar across race and did not materially vary by histotype.
This is one of the largest studies to date to compare the associations between genital powder use and ovarian cancer risk, overall and by histotype, between African-American and White women.
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Details
- Title
- Genital Powder Use and Risk of Epithelial Ovarian Cancer in the Ovarian Cancer in Women of African Ancestry Consortium
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.30(9), pp.1660-1668
- Resource Type
- Journal article
- Publisher
- American Association for Cancer Research
- Grant note
- 75N94021D00002 / NICHD NIH HHS HHSN268201600003C / NHLBI NIH HHS R01 CA076016 / NCI NIH HHS 75N90021D00002 / CLC NIH HHS HHSN268201600001C / NHLBI NIH HHS K01 CA212056 / NCI NIH HHS UM1 CA173642 / NCI NIH HHS U01 CA164974 / NCI NIH HHS 75N99021D00002 / ORFDO NIH HHS UM1 CA164974 / NCI NIH HHS R01 CA142081 / NCI NIH HHS HHSN268201600018C / NHLBI NIH HHS R01 CA058420 / NCI NIH HHS 75N98021D00002 / NIH HHS R01 CA058598 / NCI NIH HHS HHSN268201600004C / NHLBI NIH HHS HHSN268201600002C / NHLBI NIH HHS P01 CA017054 / NCI NIH HHS P30 CA014089 / NCI NIH HHS R01 CA207260 / NCI NIH HHS
- Identifiers
- WOS:000696386200010; 99380570897106600
- Academic Unit
- Public Health; Usha Kundu, MD College of Health
- Language
- English