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Journal article
Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals
Experimental Gerontology, Vol.40, pp.416-425
40
2005
PMID: 15919594
Web of Science ID: WOS:000229814200010
Abstract
Endurance exercise provides cardioprotection against ischemia-reperfusion (IR)-induced necrotic cell death in young animals. However, whether exercise-induced cardioprotection prevents IR-induced apoptosis in young and old animals is unknown. We tested the hypothesis that endurance exercise training will attenuate IR-induced myocardial apoptosis in young (4 months) and old (24 months) male F344 rats. Young and old rats remained sedentary or performed multiple bouts of moderate intensity running exercise. To induce apoptosis, isolated working hearts were exposed to 45 min of ischemia followed by 90 min of reperfusion. Assessment of myocardial levels of caspase-3 cleaved alpha-spectrin and TUNEL labeled nuclei revealed that IR resulted in apoptosis in hearts from both young and old animals. Importantly, independent of age, exercise attenuated the IR-induced apoptosis of cardiac myocytes. Moreover, exercise attenuated IR-induced calpain activation in the hearts of both young and old animals. These experiments for the first time demonstrate that exercise attenuates IR-induced myocardial apoptosis in both young and old animals. Potential mechanisms for this exercise-induced cardioprotection against IR-induced apoptosis include improved myocardial antioxidant capacity and prevention of calpain and caspase-3 activation.
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Details
- Title
- Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals
- Publication Details
- Experimental Gerontology, Vol.40, pp.416-425
- Resource Type
- Journal article
- Publisher
- Elsevier Inc.; United States
- Series
- 40
- Copyright
- © 2005 Elsevier Inc. All rights reserved.
- Identifiers
- WOS:000229814200010; 99380090769206600
- Academic Unit
- Movement Sciences and Health; Usha Kundu, MD College of Health
- Language
- English