Logo image
Back
Exercise does not increase cyclooxygenase-2 myocardial levels in young or senescent hearts
Journal article   Open access   Peer reviewed

Exercise does not increase cyclooxygenase-2 myocardial levels in young or senescent hearts

John C. Quindry, Joel French, Karyn L. Hamilton, Youngil Lee, Josh Selsby and Scott Powers
The journal of physiological sciences, Vol.60(3), pp.181-186
05/01/2010
DOI: https://doi.org/10.1007/s12576-009-0082-2
PMCID: PMC2854316
PMID: 20054720
Web of Science ID: WOS:000276541800002

Metrics

32 Record Views
19 Times Cited - Web of Science

Abstract

Increased myocardial cyclooxygenase-2 (COX-2) activity is essential for late phase ischemic preconditioning (IPC). Currently unknown is whether cardioprotection elicited by exercise also involves elevated myocardial COX-2 activity. This investigation tested whether aerobic exercise elevates myocardial COX-2 protein content or enzyme activity in young and senescent male Fisher 344 rats assigned to sedentary or cardioprotective endurance exercise treatments (3 consecutive days of treadmill exercise, 60 min/day @similar to 70% VO(2)max). Assay of cardiac COX-2 protein content, catalytic activity, and inducible nitric oxide synthase (iNOS) protein content reveal that exercise did not alter COX-2 activity (PGE(2), p = 0.866; PGF1 alpha, p = 0.796) or protein levels (p = 0.397) within young or senescent hearts. In contrast, myocardial iNOS, an up-stream mediator of COX-2 expression, was over-expressed by an average of 37% in aged hearts (p = 0.005), though iNOS was not influenced by exercise. Findings reveal exercise does not elevate cardiac COX-2 activity and suggests that mechanisms responsible for cardioprotection differ between IPC and aerobic exercise.
url
https://doi.org/10.1007/s12576-009-0082-2View
Published (Version of record) Open

Related links

Details

Logo image