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Journal article
Excitotoxicity: Perspectives based on N-methyl-D-aspartate receptor subtypes
Journal of Pharmacology and Experimental Therapeutics, Vol.300(3), pp.717-723
300
2002
PMID: 11861773
Web of Science ID: WOS:000174059900001
Abstract
Since excitotoxicity has been implicated in a variety of neuropathological conditions, understanding the pathways involved in this type of cell death is of critical importance to the future clinical treatment of many diseases. The N-methyl-D-aspartate (NMDA) receptor has become a primary focus of excitotoxic research because early studies demonstrated that antagonism of this receptor subtype was neuroprotective. However, initial pharmacological agents were not clinically useful due to the adverse effects of complete NMDA receptor blockade. Understanding the biochemical properties of the multitude of NMDA receptor subtypes offers the possibility of developing more effective and clinically useful drugs. With the discovery of the basis of heterogeneity of NMDA receptors through molecular biological approaches, many new potential therapeutic targets have been uncovered, and several model systems have been developed for the study of NMDA receptor-mediated cell death. This review discusses these models and the current understanding of the relationship between NMDA receptor subtypes and excitotoxicity.
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Details
- Title
- Excitotoxicity
- Publication Details
- Journal of Pharmacology and Experimental Therapeutics, Vol.300(3), pp.717-723
- Resource Type
- Journal article
- Publisher
- American Society for Pharmacology and Experimental Therapeutics (ASPET); United States
- Series
- 300
- Grant note
- This work was supported by Grants NS01789, NS39126, and DA07130 from the National Institutes of Health, a Beeson Scholar Award, and a Junior Investigator Award from the National Alliance for Research on Schizophrenia and Depression.
- Copyright
- The Publisher maintains Journals as a service to its members and the scientific/technical/ medical community. The Publisher holds the copyright for all works published in Journals, as a compilation and as to the individual articles, collectively and individually, unless otherwise expressly noted.
- Identifiers
- WOS:000174059900001; 99380090870806600
- Academic Unit
- Biology; Hal Marcus College of Science and Engineering
- Language
- English