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Journal article
Evaluation of potential health effects associated with serum polychlorinated biphenyl levels
Environmental health perspectives, Vol.70, pp.255-259
12/01/1986
PMID: 3104024
Web of Science ID: WOS:A1986G349000026
Abstract
In late 1983, we conducted a cross-sectional epidemiologic study to evaluate persons at risk of exposure to three chemical waste sites by comparing clinical disease end points and clinical chemistry parameters with serum polychlorinated biphenyls (PCB) levels. A total of 106 individuals participated in the study. The only statistically significant finding in regard to self-reported, physician-diagnosed health problems was a dose-response relationship between serum PCB levels and the occurrence of high blood pressure; however, this association failed to achieve statistical significance (p = 0.08) when we controlled for possible confounding effects of both age and smoking. Serum triglyceride and cholesterol levels were also higher in the group with elevated serum PCBs; additionally, there were isolated statistically significant correlations of serum aspartate aminotransferase (SGOT) with serum lipid fraction-adjusted PCB level (r = -0.21) and serum albumin (r = -0.24) and total bilirubin (r = 0.30) with serum PCB level. Although the ranges of serum levels reported herein from exposures to PCBs in the general environment are lower than those that have been associated with acute symptoms or illness in other studies, whether these levels are associated with long-term health risks is not known. Associations of such chronic, low-dose exposures with observable health effects as suggested by this study must be evaluated further before any final conclusions can be drawn.
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- Title
- Evaluation of potential health effects associated with serum polychlorinated biphenyl levels
- Publication Details
- Environmental health perspectives, Vol.70, pp.255-259
- Resource Type
- Journal article
- Publisher
- U.S. Department of Health and Human Services * National Institute of Environmental Health Sciences
- Format
- link
- Copyright
- EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
- Identifiers
- WOS:A1986G349000026; 99380178993606600
- Academic Unit
- Public Health; Usha Kundu, MD College of Health
- Language
- English