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Journal article
Enantioselective Total Synthesis of (+)-Fusicoccadiene via Photocatalytic Polyene Isomerization
Journal of the American Chemical Society, Vol.148(1), pp.124-129
01/14/2026
PMID: 41472317
Web of Science ID: WOS:001651836600001
Abstract
The fusicoccane diterpenes have amassed interest for their intricate 5-8-5 tricyclic framework and ability to interface with diverse signaling proteins. Herein, we report an enantioselective synthetic platform for the rapid assembly of fusicoccanes where the 5-8-5 motif is prepared via valence bond isomerization of a polyene precursor. A series of regio- and stereoselective modifications to the periphery of this substructure provides entry to diverse fusicoccane congeners. The utility of this strategy is demonstrated with a concise total synthesis of (+)-fusicoccadiene.
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Details
- Title
- Enantioselective Total Synthesis of (+)-Fusicoccadiene via Photocatalytic Polyene Isomerization
- Publication Details
- Journal of the American Chemical Society, Vol.148(1), pp.124-129
- Resource Type
- Journal article
- Publisher
- American Chemical Society
- Number of pages
- 6
- Grant note
- NA / W. Herz Endowment R01-GM125926 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Copyright
- © 2025 American Chemical Society
- Identifiers
- WOS:001651836600001; 99381856993106600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English