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Journal article
Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice
Annals of Hepatology, Vol.19, pp.69-78
19
2020
PMID: 31611063
Web of Science ID: WOS:000505778600011
Abstract
Introduction and objectives
Endurance exercise (EXE) has emerged as a potent inducer of autophagy essential in maintaining cellular homeostasis in various tissues; however, the functional significance and molecular mechanisms of EXE-induced autophagy in the liver remain unclear. Thus, the aim of this study is to examine the signaling nexus of hepatic autophagy pathways occurring during acute EXE and a potential crosstalk between autophagy and apoptosis.
Materials and methods
C57BL/6 male mice were randomly assigned to sedentary control group (CON, n = 9) and endurance exercise (EXE, n = 9). Mice assigned to EXE were gradually acclimated to treadmill running and ran for 60 min per day for five consecutive days.
Results
Our data showed that EXE promoted hepatic autophagy via activation of canonical autophagy signaling pathways via mediating microtubule-associated protein B-light chain 3 II (LC3-II), autophagy protein 7 (ATG7), phosphorylated adenosine mono phosphate-activated protein kinase (p-AMPK), CATHEPSIN L, lysosome-associated membrane protein 2 (LAMP2), and a reduction in p62. Interestingly, this autophagy promotion concurred with enhanced anabolic activation via AKT-mammalian target of rapamycin (mTOR)-p70ˢ⁶ᴷ signaling cascade and enhanced antioxidant capacity such as copper zinc superoxide dismutase (CuZnSOD), glutathione peroxidase (GPX), and peroxiredoxin 3 (PRX3), known to be as antagonists of autophagy. Moreover, exercise-induced autophagy was inversely related to apoptosis in the liver.
Conclusions
Our findings indicate that improved autophagy and antioxidant capacity, and potentiated anabolic signaling may be a potent non-pharmacological therapeutic strategy against diverse liver diseases.
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Details
- Title
- Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice
- Publication Details
- Annals of Hepatology, Vol.19, pp.69-78
- Resource Type
- Journal article
- Publisher
- Asociacion Mexicana de Hepatologia; Mexico
- Series
- 19
- Format
- pdf
- Copyright
- © 2019 Fundacion´ Clınica ´ Medica ´ Sur, A.C. Published by Elsevier Espana, ˜ S.L.U. This is an open access article under the CC BY-NC-ND license
- Identifiers
- WOS:000505778600011; 99380090771206600
- Academic Unit
- Usha Kundu, MD College of Health; Movement Sciences and Health
- Language
- English