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Journal article
DMTSF-mediated electrophilic cyclization for the synthesis of 3-thiomethyl-substituted benzo[b]furan derivatives
Organic & biomolecular chemistry, Vol.23(8), pp.1735-1736
02/28/2025
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Abstract
Benzofuran is an important backbone for molecules that make up several pharmaceuticals, herbicides/pesticides, and organo-electronics. An environmentally benign dimethyl(methylthio)sulfonium tetrafluoroborate salt was used as an electrophile to induce cyclization of o-alkynyl anisoles to form 2,3-disubstituted benzofurans. The cyclization is performed at ambient reaction conditions, only takes 12 hours to get excellent yields, and shows a high tolerance for various substituted alkynes. Also, a trimethyl group obtained after the cyclization reactions allows for a cascade cyclization, and an alkyne is used in the reaction to create a thieno[3,2-b]benzofuran core structure.
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Details
- Title
- DMTSF-mediated electrophilic cyclization for the synthesis of 3-thiomethyl-substituted benzo[b]furan derivatives
- Publication Details
- Organic & biomolecular chemistry, Vol.23(8), pp.1735-1736
- Resource Type
- Journal article
- Publisher
- Royal Society of Chemistry
- Copyright
- © Royal Society of Chemistry
- Identifiers
- 99380579778306600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Chemistry; Biology
- Language
- English