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Journal article
Contrasting DNA methylation responses of inbred fish lines to different rearing environments
Epigenetics, Vol.14(10), pp.939-948
10/03/2019
PMID: 31144573
Web of Science ID: WOS:000475283900001
Abstract
Epigenetic mechanisms generate plastic phenotypes that can become locally adapted across environments. Disentangling genomic from epigenomic variation is challenging in sexual species due to genetic variation among individuals, but it is easier in self-fertilizing species. We analysed DNA methylation patterns of two highly inbred strains of a naturally self-fertilizing fish reared in two contrasting environments to investigate the obligatory (genotype-dependent), facilitated (partially depend on the genotype) or pure (genotype-independent) nature of the epigenetic variation. We found higher methylation differentiation between genotypes than between environments. Most methylation differences between environments common to both strains followed a pattern where the two genotypes (inbred lines) responded to the same environmental context with contrasting DNA methylation levels (facilitated epialleles). Our findings suggest that, at least in part, DNA methylation could depend on the dynamic interaction between the genotype and the environment, which could explain the plasticity of epigenetically mediated phenotypes.
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Details
- Title
- Contrasting DNA methylation responses of inbred fish lines to different rearing environments
- Publication Details
- Epigenetics, Vol.14(10), pp.939-948
- Resource Type
- Journal article
- Publisher
- Taylor & Francis Inc.
- Copyright
- © 2019 Informa UK Limited, trading as Taylor & Francis Group
- Identifiers
- WOS:000475283900001; 99380569197006600
- Academic Unit
- Biology
- Language
- English