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Journal article
Contemporaneous Dual Catalysis: Aldol Products from Non-Carbonyl Substrates
Chemistry : a European journal, Vol.21(43), pp.15108-15112
10/19/2015
PMID: 26334442
Web of Science ID: WOS:000363332200006
Abstract
The aldol reaction represents an important class of atom-economic carbon-carbon bond-forming reactions vital to modern organic synthesis. Despite the attention this reaction has received, issues related to chemo- and regioselectivity as well as reactivity of readily enolizable electrophiles remain. To help overcome these limitations, a new direct approach toward aldol products that does not rely upon carbonyl substrates is described. This approach employs room-temperature contemporaneous lanthanum/vanadium dual catalysis, whereby a vanadium-catalyzed 1,3-transposition of allenols is coupled with a lanthanum-catalyzed Meinwald rearrangement of epoxides in situ to directly form aldol products.
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Details
- Title
- Contemporaneous Dual Catalysis
- Publication Details
- Chemistry : a European journal, Vol.21(43), pp.15108-15112
- Resource Type
- Journal article
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- CHE-1360634 / NSF; National Science Foundation (NSF)
- Copyright
- © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Identifiers
- WOS:000363332200006; 99381709174106600
- Academic Unit
- Chemistry; Hal Marcus College of Science and Engineering
- Language
- English