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Journal article
Calpains: Intact and active?
Bioessays, Vol.19, pp.1011-1018
19
1997
PMID: 9394623
Web of Science ID: WOS:A1997YF79900010
Abstract
Calpains are a family of calcium-dependent thiol-proteases which are proposed to be involved in many physiological processes as well as pathological conditions. Calpains are likely to be involved in processing of numerous enzymes and cytoskeletal components, thereby linking their activity to a variety of intracellular events. Although widely studied, the precise mechanism(s) involved in calpain activation and activity in vivo remain poorly understood. Initial studies suggested that calpain exists primarily as an inactive proenzyme that required autolytic cleavage for activation. It was also hypothesized that calpain associated with membrane phospholipids, serving to increase calcium sensitivity, facilitating autolytic conversion and thus activating the enzyme. These hypotheses, however, have not been universally accepted and there is increasing evidence that intact, non-autolyzed calpain is the physiologically active calpain form.
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Details
- Title
- Calpains
- Publication Details
- Bioessays, Vol.19, pp.1011-1018
- Resource Type
- Journal article
- Publisher
- John Wiley & Sons, Ltd.; United Kingdom
- Series
- 19
- Copyright
- © 1997 Cambridge University Press
- Identifiers
- WOS:A1997YF79900010; 99380090615706600
- Academic Unit
- Biology; Hal Marcus College of Science and Engineering
- Language
- English