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Journal article
Boldine Alters Serum Lipidomic Signatures after Acute Spinal Cord Transection in Male Mice
International journal of environmental research and public health, Vol.20(16), p.6591
08/17/2023
PMID: 37623175
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Abstract
Traumatic spinal cord injury (SCI) results in wide-ranging cellular and systemic dysfunction in the acute and chronic time frames after the injury. Chronic SCI has well-described secondary medical consequences while acute SCI has unique metabolic challenges as a result of physical trauma, in-patient recovery and other post-operative outcomes. Here, we used high resolution mass spectrometry approaches to describe the circulating lipidomic and metabolomic signatures using blood serum from mice 7 d after a complete SCI. Additionally, we probed whether the aporphine alkaloid, boldine, was able to prevent SCI-induced changes observed using these 'omics platforms'. We found that SCI resulted in large-scale changes to the circulating lipidome but minimal changes in the metabolome, with boldine able to reverse or attenuate SCI-induced changes in the abundance of 50 lipids. Multiomic integration using xMWAS demonstrated unique network structures and community memberships across the groups.
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- Title
- Boldine Alters Serum Lipidomic Signatures after Acute Spinal Cord Transection in Male Mice
- Publication Details
- International journal of environmental research and public health, Vol.20(16), p.6591
- Resource Type
- Journal article
- Publisher
- MDPI
- Grant note
- UC2ES030158 / NIH HHS U2C ES030158 / NIEHS NIH HHS IK2 RX002781 / RRD VA I50 RX002020 / RRD VA
- Copyright
- © by the authors.
- Identifiers
- 99380570796606600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Biology
- Language
- English