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Journal article
Acute high-intensity exercise enhances T cell proliferation compared to moderate-intensity exercise
Applied physiology, nutrition, and metabolism, Vol.50, 0420
03/13/2025
PMID: 39947139
Web of Science ID: WOS:001443619200001
Abstract
Conventional belief is that high-intensity (HI) exercise inhibits immune function; however, recent work challenges this position. The purpose of this was to quantify changes in T cell proliferative capacity following either a HI or moderate-intensity (MI) exercise. Sixteen males were randomly selected to a HI or MI exercise group. Blood was obtained baseline and immediately, 1-, 4-, and 6-hours post-exercise for analyses of CD3+ T cell proliferation (co-stimulation via PHA or CD3+CD28). The proliferative response increased in T cells in the HI group and remained significantly elevated up to 6-hours post-exercise in both co-stimulation conditions. In contrast, the MI group saw no change proliferative ability following exercise. Analyses of serum stress hormones, and immunomodulatory cytokines failed to reveal any correlated variations that could clarify the T cell findings. We suggest the increase in proliferative capacity following HI exercise is indicative of an exercise-induced activation that provides for enhanced functional responses to stimuli. Moreover, this study shows that HI exercise increases T cell processes, effectively priming them for activation in response to stimuli. This study is registered with ClinicalTrials.gov (NCT06638684).
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Details
- Title
- Acute high-intensity exercise enhances T cell proliferation compared to moderate-intensity exercise
- Publication Details
- Applied physiology, nutrition, and metabolism, Vol.50, 0420
- Resource Type
- Journal article
- Publisher
- Canadian Science Publishing; OTTAWA
- Number of pages
- 12
- Grant note
- University of Kansas General Research FundOffice of Naval Research (ONR): N000141410202
This project was supported, in part, by the University of Kansas General Research Fund and a grant through the Office of Naval Research (ONR N000141410202).
- Copyright
- © 2025 The Author(s).
- Identifiers
- WOS:001443619200001; 99381273008506600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Biology
- Language
- English