Metrics
2 Record Views
Journal article
Acute Effect of E-Cigarette Inhalation on Mucociliary Clearance in E-Cigarette Users
Journal of aerosol medicine and pulmonary drug delivery, Vol.37(4), pp.167-170
08/2024
PMID: 38687136
Web of Science ID: WOS:001209890800001
Abstract
Recent studies show e-cigarette (EC) users have increased rates of chronic bronchitic symptoms that may be associated with depressed mucociliary clearance (MCC). Little is known about the acute or chronic effects of EC inhalation on in vivo MCC.
MCC was measured in young adult vapers (n = 5 males, mean age = 21) after controlled inhalation of a radiolabeled (Tc99m sulfur colloid) aerosol. Whole-lung clearance of radiolabeled deposited particles was measured over a 90-minute period for baseline MCC and associated with controlled periodic vaping over the first 60 minutes of MCC measurements. The vaping challenge was administered from a fourth generation box mod EC containing unflavored e-liquid (65% propylene glycol/35% vegetable glycerin, 3 mg/mL freebase nicotine). The challenge was administered at the start of each 10-minute interval of MCC measurements and consisted of 1 puff every 30 seconds for 5 minutes (i.e., 10 puffs for each 10-minute period for a total of 60 puffs during the initial 60 minutes of MCC measurements).
Compared with baseline, peripheral lung average clearance (%) over the 90 minutes of MCC measures was enhanced, associated with EC challenge, 12 (±6) versus 24 (±6), respectively (p < 0.05 by Wilcoxon signed-rank test).
Acute enhancement of in vivo MCC during EC challenge is contrary to recent studies showing nicotine-associated slowing of ciliary beat and mucus transport at higher nicotine levels than those used here. However, our findings are consistent with an acute increase in fluid volume and mucin secretion to the bronchial airway surface that is likely short lived.
Related links
Details
- Title
- Acute Effect of E-Cigarette Inhalation on Mucociliary Clearance in E-Cigarette Users
- Publication Details
- Journal of aerosol medicine and pulmonary drug delivery, Vol.37(4), pp.167-170
- Resource Type
- Journal article
- Publisher
- Mary Ann Liebert, Inc.
- Number of pages
- 4
- Grant note
- ISAM 2021 abstract: NIHR01HL139369
The data that support the findings of this study are available from the corresponding author [W.D.B.] upon reasonable request. These results were previously published in part as an ISAM 2021 abstract. Grant number: NIHR01HL139369.
- Copyright
- © 2024, Mary Ann Liebert, Inc.
- Identifiers
- WOS:001209890800001; 99381559030306600
- Academic Unit
- Usha Kundu, MD College of Health; Health Sciences and Administration
- Language
- English