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Journal article
A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985
Phosphorus, sulfur, and silicon and the related elements, Vol.197(8), pp.876-884
09/21/2022
Web of Science ID: WOS:000808506400001
Abstract
This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. In addition, several compounds caused cytotoxicity at high cell densities. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.
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Details
- Title
- A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985
- Publication Details
- Phosphorus, sulfur, and silicon and the related elements, Vol.197(8), pp.876-884
- Resource Type
- Journal article
- Publisher
- Taylor & Francis
- Number of pages
- 9
- Grant note
- We gratefully acknowledge the financial support for NA and KF through the Office of Undergraduate Research at the University of West Florida. KF was supported by NIH grant T34GM110517. KF is grateful to NIH for support through the Institute of General Medical Sciences of the National Institutes of Health under grant number 1T34GM110517-01. This content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Copyright
- © 2022 Taylor & Francis
- Identifiers
- WOS:000808506400001; 99380171995106600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Biology
- Language
- English