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Journal article
A region of the rat N-methyl-D-aspartate receptor 2A subunit that is sufficient for potentiation by phorbol esters
Neuroscience Letters, Vol.310, pp.9-12
310
2001
PMID: 11524145
Web of Science ID: WOS:000170855900003
Abstract
N-methyl-D-aspartate (NMDA) receptors are modulated by protein kinase C (PKC) in vivo and in heterologous expression systems. In heterologous expression systems, PKC-mediated modulation is subunit specific with NR2A-containing receptors being potentiated by phorbol 12-myristate 13-acetate (PMA), while NR2C-containing receptors are inhibited or unaffected. In the present study we have produced chimeric receptors containing NR2A and NR2C to define the components of NR2A which are sufficient for potentiation by PMA. Amino acids 1105-1400 of NR2A placed onto the C-terminus of NR2C at amino acid 1102 was the minimum region sufficient for producing a PMA-stimulated receptor. This suggests that this region contains structural determinants for PKC-mediated potentiation of NR2A receptors.
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Details
- Title
- A region of the rat N-methyl-D-aspartate receptor 2A subunit that is sufficient for potentiation by phorbol esters
- Publication Details
- Neuroscience Letters, Vol.310, pp.9-12
- Resource Type
- Journal article
- Publisher
- Elsevier Ireland Ltd.; Ireland
- Series
- 310
- Copyright
- © 2001 Elsevier Science Ireland Ltd.
- Identifiers
- WOS:000170855900003; 99380090892206600
- Academic Unit
- Biology; Hal Marcus College of Science and Engineering
- Language
- English