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Journal article
A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?
Current rheumatology reports, Vol.23(11), 78
11/01/2021
PMCID: PMC8556166
PMID: 34716494
Web of Science ID: WOS:000712817800001
Abstract
Osteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure.
This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements. The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.
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Details
- Title
- A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates
- Publication Details
- Current rheumatology reports, Vol.23(11), 78
- Resource Type
- Journal article
- Publisher
- Springer Healthcare; United States
- Format
- link
- Grant note
- P30 DK048520 / NIDDK NIH HHS
- Copyright
- © 2021, The Author(s)
- Identifiers
- WOS:000712817800001; 99380504596806600
- Academic Unit
- Usha Kundu, MD College of Health; Movement Sciences and Health
- Language
- English