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Journal article
A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines
Angewandte Chemie (International ed.), Vol.48(6), pp.1138-1143
01/01/2009
PMID: 19115342
Web of Science ID: WOS:000263082300022
Abstract
Isoquinoline ring the changes: A novel strategy for the title reaction involves ortho-haloarylalkynes which undergo sequential intermolecular addition of N heterocycles onto alkynes and subsequent intramolecular ring closure by arylation. The process involves the use of hydroxymethyl benzotriazole as an efficient and inexpensive ligand for the C—N and C—C coupling reactions.
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Details
- Title
- A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines
- Publication Details
- Angewandte Chemie (International ed.), Vol.48(6), pp.1138-1143
- Resource Type
- Journal article
- Publisher
- Wiley-VCH Verlag GmbH & Co. KGaA; Weinheim
- Grant note
- Department of Science and Technology (DST) Government of India; Department of Science & Technology (India) R01GM070620 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) GM 070620; GM 079593 / National Institute of General Medical Science; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Copyright
- © 2009 Wiley-VCH Verlag GmbH & Co. KGaA
- Identifiers
- WOS:000263082300022; 99380480677506600
- Academic Unit
- Hal Marcus College of Science and Engineering ; Chemistry
- Language
- English