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effects of blue monochromatic light on variability in the FVEP-P2
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effects of blue monochromatic light on variability in the FVEP-P2

Jessica Steele
University of West Florida,
Master of Arts (MA), University of West Florida
2020

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Abstract

Early diagnosis of AD (Alzheimer's dementia) is imperative for treatment research to continue. The flash visual evoked potential P2 (FVEP-P2) has been shown to distinguish healthy controls from AD patients. It is a measure of cholinergic functioning within the brain which is impaired in those with AD due to the decline in acetylcholine (ACh). Previous research shows that the variability remains too high for this biomarker to be used as a clinically diagnostic tool at this time. In order to reduce variability, researchers have been manipulating the process in which the VEP waveform is produced. One promising effort is to change the light composition used to elicit the VEP. Research has been conducted to suggest that the use of blue monochromatic light may reduce variability seen in the P2. The present investigation sought to replicate these findings by comparing the traditional white to a blue strobe flash stimulus. Healthy individuals (N=24) were recruited from the University of West Florida and participated in this study to examine the psychometric properties of the white and blue light conditions. Results indicate that blue light may have the opposite effect, raising the variability in both latency and amplitude compared to that of white light. Based on these results, we suggest using an automatic algorithm for selecting the FVEP-P2 when using a white light.
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