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Thesis
The Effects Of Ketone Supplementation And Pharmacological Exercise Mimetic On Doxorubicin-Induced Cardiotoxicity
University of West Florida Libraries
Master of Science (MS), University of West Florida
2023
Abstract
Humans have been afflicted with cancer, in many forms, for thousands of years. In the United States, more than 250 years of cancer research has provided breakthroughs in identifying and treating different types of cancer. Many of these treatments, though effective, are accompanied with adverse side effects. This is true of chemotherapy treatments, which often cause hair loss, weight loss, and nausea (Sugerman, 2013). Though these side effects are often acute, lasting for only the duration of the treatment, some chemotherapy drugs have chronic side effects. Doxorubicin (DOX), a chemotherapy drug that is effective at treating many forms of cancer, increases the risk of developing cardiotoxicity resulting in heart failure (Rivankar, 2014). Finding a way to mitigate this potential life-threatening side effect would improve the long-term survivability and quality of life for people treated with DOX. Two interventions have emerged as potential therapies mitigate the undesirable side effects: beta-hydroxybutyrate (BHB)—a ketone body—and exercise. Studies like those conducted by Liu et al. (2020) and Wu et al. (2019) provide evidence that ketone bodies and exercise may improve cellular mechanisms that contribute to DOX-induced cardiotoxicity. The potential protective mechanisms of these two interventions remain to be elucidated. Thus, the objective of this study was to examine the effects BHB and exercise mimetic pretreatment had on cellular antioxidant production, autophagy, and mitochondrial biogenesis on cells treated with DOX. Additionally, this study examined the potential synergistic effects of pretreatment with combination of BHB and an exercise mimetic before DOX treatment.
Details
- Title
- The Effects Of Ketone Supplementation And Pharmacological Exercise Mimetic On Doxorubicin-Induced Cardiotoxicity
- Resource Type
- Thesis
- Contributors
- Youngil Lee (Committee Chair)Ludmila Cosio-Lima (Committee Member)Amy Crawley (Committee Member)Chris Worth (Committee Member)
- Publisher
- University of West Florida Libraries
- Format
- pdf
- Number of pages
- 80
- Copyright
- Permission granted to the University of West Florida Libraries by the author to digitize and/or display this information for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380461595906600
- Academic Unit
- Movement Sciences and Health; Usha Kundu, MD College of Health
- Language
- English
- Awarding Institution
- University of West Florida; Master of Science (MS)
- Theses and Dissertations
- Master of Science (MS), University of West Florida