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Thesis
Effects of Endurance Exercise on Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
University of West Florida Libraries
Master of Science (MS), University of West Florida
Spring 2022
Abstract
Non-Alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases affecting 25% of the population of the United States. The primary cause of NAFLD is metabolic distress incurred by obesity and diabetes. Although no cure is available, regular endurance exercise (EXE) has emerged as an effective non-pharmacological strategy. However, its molecular mechanisms are incompletely understood. Using a mouse model of NAFLD induced by a high-fat diet (obesity) and streptozotocin (type II diabetes), the present study explored a potential molecular signaling nexus linked to EXE-induced protection against NAFLD. Our study showed that 15 weeks of EXE significantly attenuated hepatic steatosis caused by a high-fat diet with streptozotocin. The mechanisms responsible for EXE-induced protection were:1. EXE improved fatty acid oxidation in the mitochondria.
2. EXE reduced endoplasmic reticulum stress.
3. EXE potentiated antioxidant capacity and autophagy.
Despite displaying conspicuous hepatic steatosis, sedentary obese diabetic mice did not show significant hepatocyte disruption. This observation suggests that hepatic steatosis may not cause cellular deterioration but that a transition to exacerbating progression due to extended metabolic distress may be responsible for massive hepatocyte injuries. Collectively, our study indicates that EXE may play a crucial role in preventing metabolic distress-induced hepatosteatosis.
Details
- Title
- Effects of Endurance Exercise on Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
- Resource Type
- Thesis
- Contributors
- Youngil Lee (Advisor)Ludmilia Cosio-Lima (Committee Member)Amy Crawley (Committee Member)
- Publisher
- University of West Florida Libraries
- Format
- pdf
- Number of pages
- 69
- Copyright
- © 2020 Jocelyn Esther Arnett
- Identifiers
- 99380090596406600
- Academic Unit
- Movement Sciences and Health; Usha Kundu, MD College of Health
- Language
- English
- Awarding Institution
- University of West Florida; Master of Science (MS)
- Theses and Dissertations
- Master of Science (MS), University of West Florida